Cuenca is considered the most beautiful city (and third largest) in Ecuador, and boasts a quaint combination of old and new: colonial architecture shares space with art galleries, museums, and vibrant cafés. Wander cobblestone streets exploring city sights, with a stop at the main plaza to see the old Cathedral. It was built in 1557, when Cuenca was founded by the Spanish conquerors. Looking for some outdoor adventure? Head out to the beautiful countryside to play in the nearby national park.